December 4th, 2019, Boston, USA
“Gene Regulation in Differentiation and Cancer”
8:45-9:15 Registration and Continental breakfast
9:15-9:30 Opening Remarks
Alan Rosmarin, M.D.
9.30-11:15 Session I:
Chair: Dr. Alan Rosmarin
9.30-10:00 Keynote Speaker
Jonathan Licht M.D.
Director- The University of Florida Health Cancer Center,
The Marshall E. Rinker, Sr. Foundation and David B. and Leighan R. Rinker Chair
Disorders of histones and histone methylation in cancer
10:00 to 10:15 Ulrich Steidl, M.D. Ph.D.
Lineage Commitment and Differentiation – 15 years later
10:15-1:30 Shannon Elf, Ph.D.
Identifying novel molecular dependencies in CALR-mutated myeloproliferative neoplasms
10:30-10:45 Huimin Chen, M.D. Ph.D.
3D Bioprinting Application in Cartilage Repair
10:45-11:00 Annalisa DiRuscio, M.D. Ph.D.
RNAs: the real writers of the epigenetic code
11:00-11:15 Sophia Adamia, Ph.D.
AML epigenetics for the 21st century: novel biomarkers and drug targets
11:15-12:30 Session II
Chair: Dr. Ulrich Steidl
11:15-11:30 Dong-Er Zhang, Ph.D.
Dynamics of RASSF2 in leukemogenesis
11:30-11:45 Justin Wheat, Ph.D.
Single Molecule Analysis of Spi1 Transcription Dynamics During Differentiation
11:45-12:00 Meritxell Alberich-Jorda, Ph.D.
Chronic inflammation, stem cells and leukemia
12:00-12:15 Britta Will, Ph.D.
Novel safeguards of hematopoietic stem cell identity
12:15-12:30 Barbara Wegiel, Ph.D.
Scavenging of free heme by hemopexin is a key check-point in cancer growth and metastases
12:30-1:30 Lunch break
1:30-3:30 Session III
Chair: Dr. Dong-Er Zhang
1:30-2:00 Keynote Speaker
David Livingston, M.D.,
Deputy Director, Dana-Farber/Harvard Cancer Center
Chief, Charles A. Dana Division of Human Cancer Genetics
Emil Frei Professor of Genetics and Medicine,
Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts
En route in a normal mammary epithelial cell to BRCA1 breast cancer
2:00-2:15 Dan Costa, M.D., Ph.D.
Dan Tenen and lung cancer: an accidental encounter that helped revolutionize precision oncology
2:15-2:30 Gang Huang, Ph.D.
Pseudohypoxia - An Underlying Mechanism and therapeutic Target of Myelodysplastic Syndromes
2:30-2:45 Hideyo Hirai, MD. Ph.D.
C/EBPbeta isoforms regulate hematopoietic stem cells under stress condition
2:45-3:00 Philipp Staber, MD. Ph.D.
Identifying functional switches in hematologic malignancies
3:00-3:15 Rob Welner, Ph.D.
Targeting Leukemia through the Marrow Microenvironment
3:15-3:30 Anne Satterthwaite, Ph.D.
Signals controlling plasma cell accumulation and autoantibody production in lupus
3:30-3:45 Coffee Break
3:45-5:30 Session IV
Chair: Dr. Dan Costa
3:45-4:00 Alan Rosmarin, MD.
A tribute to Dan Tenen
4:00-4:15 Elena Levantini, Ph.D.
Identification of a targetable KRAS-mutant epithelial population in NSCLC
4:15-4:30 Li Chai, M.D.
Targeting SALL4 in Cancer
4:30-4:45 Omid Harandi, Ph.D.
MRNA-based Engineering of Red Cell Therapeutics (RCTs) to Generate Potent, Allogeneic Cellular Therapies
4:45-5:00 Bon Trinh, Ph.D.
RNA Regulation of Promoter-Enhancer Communication
5:00-5:15 Balazs Halmos, MD. Ph.D.
Precision lung cancer medicine- a "personal" journey
5:15-5:45 Closing ceremony
Daniel G. Tenen, M.D.
5:45-6:00 Group Picture
6:00-8:30 Dinner party (Invited only)
Gene Regulation in Differentiation and Cancer
December 4th 2019
Honoring Daniel G. Tenen, M.D.
For his many contributions to the scientific community
Date: Wednesday December 4th, 2019
Time: 8:45am – 6:00pm
Location: DFCI Jimmy Fund Auditorium
Boston, MA, 02115
Symposium Committee Co-Chairs
Alan G. Rosmarin, M.D.
Deputy Editor of Hematology at UpToDate
Chief Mission Officer, the Samuel Waxman Cancer Research Foundation.
Dong-Er Zhang, Ph.D.
Professor of Pathology and Biological Sciences
University of California San Diego
Moores UCSD Cancer Center
La Jolla, CA
Ulrich Steidl, M.D., Ph.D.
Professor of Cell Biology and Medicine,
Albert Einstein College of Medicine - Montefiore Medical Center
New York, NY
Daniel Costa, M.D., Ph.D.
Associate Professor of Medicine, Harvard Medical School
Co-director Lung cancer research program within Cancer Research Institute at BIDMC
Co-leader of the lung cancer program at Dana-Farber/Harvard Cancer Center
Symposium Organizing Committee Contacts: