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Published on 4/23/2019
I’m interested in the biochemistry and molecular and cell biology of neuronal degeneration during aging of the mammalian brain, particularly in Alzheimer's diseases (AD).Also, I used Zebrafish as a model system to elucidate the molecular pathways relevant to Presenilin (PS) biology and their implication in the pathogenesis of AD and other CNS Disorders. The goals are to understand the molecular mechanism mf the PS-Dependent intramembrane cleavage of transmembrane Proteins, and to establish a Zebrafish for CNS disorders.
Zhang HY, Yang T, Zeng JZ, Zhang XK. Effects of YONG-CHUN Vinegar and Vinegar-based Soft Capsule on the Level of Serological Lipids. Research and Development of Food 2004; 5(25):121-122
Zeng JZ, Sun DF, Wang L, Cao X, Qi JB, Yang T, Hu CQ, Liu W, Zhang XK. Hypericum sampsonii Induces Apoptosis and Nuclear Export of Retinoid X Receptor-alpha. Carcinogenesis 2006; 27(10):1991-2000
Yang T, Arslanova D, Gu YL, Augelli-Szafran CE and Xia WM. Prevention of respiratory virus infections through compliance with frequent hand-washing routines. Mol Brain 2008; 4;1(1):15.
Xia WM, Yang T, Smith IM, Walsh DM and Selkoe DJ. A specific ELISA for measuring amyloid b-protein oligomers in human plasma and the brains of Alzheimer patients. Archieves in Neurology 2009 Feb;66(2):190-9.
Arslanova D, Yang T, Xu XY, Wong ST, Augelli-Szafran CE, Xia WM(2009), Phenotypic Analysis of Automatically Acquired Images of Zebrafish Treated with Alzheimer’s γ-Secretase Inhibitors, BMC Biotechnology revised
Yang T, Arslanova D, Xu XY, Li YM, Xia WM (2009), Alzheimer’s Amyloid Reducing γ-Secretase Inhibitor Induces Minimum Global Phenotypic Alteration in Zebrafish and Spares Notch Signaling
Augelli-Szafran CE, Wei HX, Lu D, Zhang J, Gu YL, Yang T, Wolfe MS, Discovery of Notch-Sparing g-Secretase Inhibitors BMC Neuroscience 2009
Zhang XK, Sun DF, Zeng JZ, Hu CQ, Yang GX, Qi QB, Yang T, Wang L, inventors; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Application of Sampson St. John’s wort extract to Regulate RXRα Target. China Patent 200510025826, 4. 2005 May 13
Zhang XK, Zeng JZ, Yang T, inventors; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Drug Screening System Based on Retinoid X Receptor Target. China Patent 200310108292, 2. 2003 Oct 31
Xia WM, Yang T, Smith IM, Walsh DM, Selkoe DJ. Monomeric and Oligomeric Aβ Assays on Plasma of Alzheimer Patients. Proceedings of the Alzheimer's Association 2008 International Conference on Alzheimer's Disease (ICAD); Chicago, USA. 2008 July
Yang T, Osenkowski P, Ye WJ, Augelli-Szafran CE, Xia WM. Quantification of γ-secretase modulation differentiates inhibitor compound selectivity between amyloid precursor protein and Notch. Proceedings of the 38th annual meeting of the Society for Neuroscience; Washington, DC. USA. 2008 Nov.
Yang T, Tuthill S, Arslanova D, Xu XY, Li Y, Xia WM. Dose-dependent inhibition of notch phenotypes in zebrafish by gamma-secretase inhibitors. Proceedings of the 38th annual meeting of the Society for Neuroscience; Washington, DC, USA. 2008 Nov.
Arslanova A, Yang T, Xu XY, Wong ST, Augelli-Szafran CE, Xia WM. Phenotypic Analysis of Automatically Acquired Images of Zebrafish Treated with Alzheimer’s γ-Secretase Inhibitors. Proceedings of the 5th International Association for Biological and Medical Research (IABMR); Boston, USA. 2008 Nov
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