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Xiang-Dong Wang

Published on 4/23/2019
Xiang-Dong Wang

Xiang-Dong Wang, M.D., Ph.D.  Director and Professor

Nutrition and Cancer Biology Laboratory

Jean Mayer USDA Human Nutrition Research Center on Aging

Tufts University
      711 Washington Street, Boston, MA 02111
      Phone: (617)556-3130  

Research interests 

Dr. Xiang-dong Wang’s Laboratory examines how carotenoids, vitamin A, vitamin D and fish oil modify molecular and genetic pathways which alter the development of cancers, such as those of the lung, colon, and liver.  This laboratory also examines how this response is modified by other exogenous factors (e.g., tobacco smoking, chronic alcohol consumption, high fat diet and chemical carcinogen exposure). Several approaches, including animal studies, molecular and cell culture studies, and human translational studies are used to elucidate the molecular mechanisms by which those nutrients prevent cancer development.  

Recent publications 

Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM and Wang X-D. The Biochemical Characterization of Ferret Carotene-9’, 10’-Monooxygenase Catalyzing Cleavage of Carotenoids in vitro and in vivo.  J Bio Chem  281; 28:19327-19338, 2006

Kim Y, Chongyviriyaphan N, Liu C, Russell RM, Wang X-D. Combined antioxidant (b-carotene, a-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. Carcinogenesis 27; 1410-1419, 2006

Lian F, Hu KQ, Russell RM, Wang X-D. b-Cryptoxanthin inhibits the growth of immortalized human bronchia epithelial cells and non-small cell lung cancer cells and up-regulates retinoic acid receptor b expression. International J Cancer 119, 2084-2089, 2006

Mernitz H, Smith D, Zhu AX, Wang X-D. Effects of 9-cis retinoic acid supplementation on COX-2 and RAR b levels and tumor formation in the lungs of NNK-induced A/J mice.  Cancer Letters 244; 101-108, 2006

Kim Y, Lian F, Yeum KJ, Russell RM, and Wang X-D. The Effects of Combined Antioxidant (b-Carotene, a-Tocopherol and Ascorbic acid) Supplementation on Antioxidant Capacity, DNA Single-Strand Break and Regulation of Insulin Growth Factor-1/IGF-Binding Protein 3 in Ferret Model of Lung Cancer.  International Journal of Cancer  120, 1847-1854, 2007

Mernitz H, Smith D, Wood R, Russell RM, and Wang X-D. Inhibition of Lung Carcinogenesis by 1a,25-Dihydroxyvitamin D3 and 9-cis Retinoic Acid in the A/J Mouse Model:  Evidence of Retinoid Antagonism of Vitamin D Toxicity.  International Journal of Cancer 120, 1402-1409, 2007

Lian F, Smith D, Ernst H, Russell RM, Wang X-D.  Lycopene metabolites, apo-10’-lycopenoic acid, inhibits the growth of lung cancer cells in vitro and suppresses lung carcinogenesis in A/J mice in vivo. Carcinogenesis 28, 1567-1574, 2007

Veeramachaneni S, Ausman LM, Choi SW, Russell RM and Wang X-D.  High dose lycopene supplementation increases hepatic CYP2E1 protein and inflammation in alcohol fed rats.  J Nutr 138:1329-1335, 2008
Wang Y, Ausman LM, Russell RM, Greenberg A and Wang X-D.  Increased apoptosis in high-fat diet induced nonalcoholic steatohepatitis is associated with JNK activation and imbalance of pro- and anti-apoptotic proteins in Bcl-2 family in rats.  J Nutr 138: 1866-1871, 2008

Lian F, and Wang X-D.  Apo-10’-lycopenoic acid induces Nrf2-mediated expression of phase II detoxification and antioxidant enzymes in human bronchial epithelial cells. International Journal of Cancer 123, 1262-1268, 2008
Wang Y, Ausman LM, Greenberg AS, Russell RM, and Wang X-D. Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine initiated early hepatocarcinogenesis in rats.  International Journal of Cancer 124: 540-546, 2009

Mernitz H, Lian F, Smith D, Meydani SN, and Wang X-D. Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse.  Nutrition and Cancer 36, 11-15, 2009

Wang Y, Ausman LM, Greenberg AS, Russell RM, and Wang X-D. Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats.  International Journal of Cancer 125: 934-939, 2009