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Qing Richard Lu

Published on 4/23/2019

Qing Richard Lu

Name: Qing Richard Lu, Ph.D.

Academic Title: Associate Professor

Primary Appointment: Developmental Biology

Secondary Appointment: Molecular Biology

School:Graduate School of Biomedical SciencesSouthwestern Medical School

Degree Program: Genetics and DevelopmentMSTP
Neuroscience

Non-degree Program: STARSSURF

Affiliations: Center for Developmental Biology

Department Website: Developmental Biology

Lab Website: Qing Richard Lu lab

Email: qrichard.lu@utsouthwestern.edu


RESEARCH OVERVIEW

The central goal of our research is to understand the molecular mechanisms of neural stem cell differentiation and neural regeneration in the central nervous system. We are particularly interested in mechanisms of gliogenesis, myelin formation, neural repair after injury and brain tumor (glioma) formation. Neuroglial cells (oligodendrocytes and astrocytes), consisting of more than 90 percent cells in our brain, play a very important role in establishment and maintenance of normal neuronal functions and formation of neurological diseases. Any brain functions, traditionally considered as the sole act of neurons, involve glial cells. Glial biology is emerging as a new frontier of current neuroscience, there is much to explore and re-explore. Using gliogenesis as a model system for neural stem cell differentiation, we have identified a number of regulatory genes important for the formation of glial cells in the CNS. We are currently utilizing multiple developmental and molecular genetic approaches to uncover the biological principles underlying myelinating cell formation and regeneration after injury.


Our current projects include:

(1) Roles of Olig1 and Olig2 in brain development and regeneration(2)Transcriptional network in regulating oligodendrocyte myelination and remyelination after injury(3) Epigenetic control of gliogenesis(4) Functional modeling of neural-glial interaction(5) Glial dysfunction-mediated neuropathic disorders RESEARCH

INTERESTS
Neural stem cell biologyOligodendrocyte myelination and repairGliogenesis and neuroregenerationGlioma formation/glioma initiating cellsGlia in neuropathic disorders

RECENT PUBLICATIONS
Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR, "HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction" Nature Neuroscience, v12:829-838 July 2009

Chen, Y. H. Wu, S. Wang, H. Koito, J. Li, J. Hoang, F. Ye, S. S. Escobar, A. Gow, H. A. Arnett, B. D. Trapp, N. J. Karandikar, J. Hsieh and Q. R. Lu, "The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell intrinsic timer of myelination" Nature Neuroscience, In press September 2009

Wang, S., Dulin, J., Wu, H., Hurlock, E., Lee, S., Jansson, K., and Lu., Q. R., "An Oligodendrocyte-Specific Zinc Finger Transcription Regulator Cooperates With Olig2 To Promote Oligodendrocyte Differentiation" Development, 133(17):3389-98 2006

Cai J., Chen Y., Cai WH., Hurlock, EC., Wu H., Kernie, SG., Parada LF., Lu QR., "A Crucial Role For Olig2 In White Matter Astrocyte Development" Development, 134:1887-1899, 2007

Chen Y., Miles, DK., Hoang, T., Shi J., Hurlock E., Kernie KG., Lu QR., "The bHLH Transcription Factor Olig2 Is Critical For Reactive Astrocyte Proliferation After Cortical Injury" J. Neurosci., 28:10983-9 2008

SIGNIFICANT PUBLICATIONS
Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR, "HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction" Nature Neuroscience, v12:829-838, July 2009

Chen, Y. H. Wu, S. Wang, H. Koito, J. Li, J. Hoang, F. Ye, S. S. Escobar, A. Gow, H. A. Arnett, B. D. Trapp, N. J. Karandikar, J. Hsieh and Q. R. Lu, "The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell intrinsic timer of myelination" Nature Neuroscience, In press September 2009

Lu QR, Cai L, Rowitch D, Cepko CL, Stiles CD., "Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex" Nat Neurosci., 109(1):75-86, 2001

Lu, Q.R., Yuk, D., Alberta, J.A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A. P., Stiles, C. D. and Rowitch, D. H., "Sonic Hedgehog-Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System." NEURON, 25:317-329, 2000

Lu, Q.R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C.D. and Rowitch, D., "Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection." Cell, 109:75-86, 2002